Global cerebral ischemia in piglets under conditions of mild and deep hypothermia.
نویسندگان
چکیده
منابع مشابه
Global cerebral ischemia in piglets under conditions of mild and deep hypothermia.
BACKGROUND AND PURPOSE To investigate the effects of hypothermia on the rate of change and degree of recovery of brain adenosine triphosphate and phosphocreatine concentrations and intracellular pH, we have developed a model that allows phosphorus nuclear magnetic resonance spectroscopy of the intact piglet brain during circulatory arrest. METHODS Three groups of piglets were studied. Three c...
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We determined whether cerebral arteriolar dilation to N-methyl-d-aspartate (NMDA), a response dependent on stimulation of cortical neurons and inhibited by anoxic stress, would be preserved by hypothermia during and following ischemia. Pial arteriolar diameters in anesthetized piglets were determined via intravital microscopy. Arteriolar responses to NMDA (10, 50, and 100 micromol/l) were measu...
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ژورنال
عنوان ژورنال: Stroke
سال: 1991
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.22.12.1567